Methanol → HCID 20230675, compound

Participants

Reaction Steps

A solution of the compound of example 6 (1.1 g, 3.7 mmole) and 11 mL CH2Cl2 was stirred under N2 at -78° C. and a solution of BBr3 (1.08 mL, 11.5 mmole) in 3.5 mL CH2Cl2 was added dropwise. The reaction mixture was stirred for 1 hr at -78°, 2 hours at 0°, and 1 hour at room temperature. After cooling again to -78°, 20 mL MeOH was added dropwise. The reaction mixture was allowed to slowly warm to room temperature overnight. Approximately 20 mL Et2O was added and the precipitate filtered, washed with 5% EtOH in Et2O, and dried (in-vacuo) to yield 0.8 g pale yellow solid; M+ 233; mp 223°-7°.

Provenance & Evidence