HCID 13746074, compound → HCID 13746076, compound

Participants

Reaction Steps

A solution of 3,4-dimethoxy-N-(2-propenyl)benzocyclobutene-1-carboxamide (13.2 g, 0.053 mole) and o-dichlorobenzene (600 mL) was stirred at reflux for 15 hours. After cooling to 0°, a solid was filtered, washed with hexane, and dried (in-vacuo) to yield 6.8 g white solid. cis And trans isomers were separated by HPLC to obtain: 1.80 g trans isomer; mp 185°-7°; M+ 247; and 3.50 g cis isomer; mp 219°-21°; M+ 247.

Provenance & Evidence