Acetic Anhydride → HCID 54325627, compound

Participants

Reaction Steps

A solution of trans-2,3,3a,4,5,9b-hexahydro-6,7-dimethoxy-1H-benz[e]isoindole hydrochloride (0.50 g, 1.9 mmole) and dry pyridine (9.5 mL) was stirred under N2 at room temperature as acetic anhydride (0.26 mL, 2.8 mmole) was added dropwise. The reaction mixture was stirred at room temperature for 0.75 hr, then was evaporated (in-vacuo). 2-Methoxyethanol was added and evaporated. The residue was dissolved in CH2Cl2 and was washed with 1N HCl, 1N KOH, water, saturated aqueous NaCl, dried (MgSO4), filtered and evaporated to yield 0.60 g white solid; M+ 275.

Provenance & Evidence