Methanesulfonic Acid → HCID 13746078, compound

Participants

Reaction Steps

A mixture of 4-(2,3-dimethoxy-5-methylphenyl)butyric acid (50.7 g, 0.21 mole) and methanesulfonic acid (507 g, 355 mL) was stirred at 0° for 1 hour and overnight at room temperature. The reaction mixture was poured onto ice, and the solution was extracted with CH2Cl2. The combined CH2Cl2 layers were washed with 1N KOH, water, saturated aqueous NaCl, dried (MgSO4), filtered, and evaporated to yield 20.2 g tan solid, (44%); mp 58°-62°; M+ 204.

Provenance & Evidence