Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | Potassium Acetate | HCID 517044 | — |
| Reactant | 1-(2-Bromo-1,1-dimethoxypropyl)-4-methoxybenzene | HCID 15579882 | — |
| Product | p-Methoxyphenylpropionic acid | HCID 257576 | 4,960% |
Reaction Steps
A mixture of 2-bromo-1,1-dimethoxy-1-(4-methoxyphenyl)-propane (3.6 g; 13 mmol), potassium acetate (2.5 g; 0.25 mmol) and formamide (25 ml) is heated at 95° C. under stirring for 6 h. The reaction mixture is worked up as described in example 1a to give 2-(4-methoxyphenyl)-propionic acid (2.2 g; 12.4 mmol; yield 96%), m.p. 56°-57° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04618697 |
|---|
| Source dataset | uspto-grants-1986_10 |
|---|
| ORD ID | ord-4ff1e02025bf499fba877c57c2dbe2f4 |
|---|
| Source note | uspto-grants-1986_10 |
|---|
