Water → p-Methoxyphenylpropionic acid

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-bromo-1,1-dimethoxy-1-(4-methoxyphenyl)-propane (2.8 g; 10 mmol), N-methylmorpholine (24 ml) and water (16 ml) is heated at 95° C., under stirring for 9 h. The reaction mixture is worked up as described in example 1a to give 2-(4-methoxyphenyl)-propionic acid (1.79 g; 9.6 mmol; yield 96%), m.p. 56°-57° C. (In this experiment, N-methyl-morpholine acts as weak base as well as dipolar aprotic diluent).

Provenance & Evidence