Potassium Acetate → Ibuprofen, (+-)-

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(1-bromoethyl)-5,5-dimethyl-2-(4-isobutylphenyl)-1,3-dioxane (3.55 g; 10 mmol), potassium acetate (1.2 g; 12 mmol), formamide (50 ml) is heated at 170° C. under stirring for 2.5 h. The reaction mixture is worked up as described in Example 1a to give 2-(4-isobutylphenyl)-propionic acid (2.5 mmol; yield 25%), m.p. 74°-76° C.

Provenance & Evidence