Benzyl Alcohol → HCID 20229699, compound

HRID 2291142Notes

Reaction equation

HRID 2291142 reaction equation
[NH:1]1[CH:5]([C:6]([OH:8])=[O:7])[CH2:4][C:3]2([CH2:13][CH:12]3[CH2:14][CH:9]2[CH2:10][CH2:11]3)[CH2:2]1.S(Cl)([Cl:17])=O.[CH2:19](O)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[ClH:17].[NH:1]1[CH:5]([C:6]([O:8][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:7])[CH2:4][C:3]2([CH2:13][CH:12]3[CH2:14][CH:9]2[CH2:10][CH2:11]3)[CH2:2]1

Participants

4

Reactant 3

HCID 244Benzyl AlcoholHCID 24386Thionyl ChlorideHCID 20187841Spiro[bicyclo[2.2.1]heptane-2,3'-pyrrolidine]-5'-carboxylic acid

Product 1

HCID 20229699HCID 20229699, compound

Procedure

4.3 g of spiro[bicyclo[2.2.1]heptane-2,3'-pyrrolidine]-5'-carboxylic acid are esterified with 43 ml of thionyl chloride and 43 ml of benzyl alcohol is analogy to the procedure described in Example 6, yield 6.7 g,

Sources & evidence

ORD record
ord-0283a3434cdb4c9ca8760cfca3799346
Source dataset
uspto-grants-1986_10
Patent number
US04620012

Reaction notes

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