反应详情

2.0 Grams of 6-(1-oxo-4-chlorobutyl)-3,4-dihydrocarbostyril was mixed with 100 ml of methanol, and the mixture was stirred at a room temperature. Then 1.0 g of sodium borohydride was added to the mixture gradually. After the reaction mixture was stirred at a room temperature for 2 hours, methanol was removed by distillation under a reduced pressure. The residue was extracted with chloroform and the chloroform layer was washed with water, and dried. Chloroform was removed by distillation under a reduced pressure, then the residue thus obtained was recrystallized from ethanol-water to obtain 1.2 g of 6-(1-hydroxy-4-chlorobutyl)-3,4-dihydrocarbostyril in colorless needle-like crystals. Melting point: 120°-121° C.

1. stirringAfter the reaction mixture was stirred at a room temperature for 2 hours
2. custommethanol was removed by distillation under a reduced pressure
3. extractionThe residue was extracted with chloroform
4. washthe chloroform layer was washed with water
5. customdried
6. customChloroform was removed by distillation under a reduced pressure
7. customthe residue thus obtained
8. customwas recrystallized from ethanol-water