Water → HCID 68864364, compound

Participants

Reaction Steps

A solution of N-(2-Phenyl-2-cyclopentylethyl)-2-chloro-3-trifluoromethylbenzylamine (218 mg, 0.57 mmol), methyl 3-(3-iodopropyloxy)-phenyl acetate (181 mg, 0.54 mmol), and MeCN (6 mL) was treated with K2CO3 (75 mg, 0.54 mmol), and the mixture was refluxed for 12 h. The reaction was diluted with H2O and extracted with Et2O. The extracts were washed with H2O, dried, and the solvent evaporated. The residue was purified via silica gel column chromatography eluted with 10% EtOAc:hexane to give the titled compound (159 mg, 50%). MS (ESI) 588 (M+H+).

Provenance & Evidence