Sodium Hydroxide → HCID 68864364, compound

Participants

Reaction Steps

A solution of N-(2-phenyl-2-cyclopentylethyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carbomethoxymethylenephenoxy)propylamine (159 mg, 0.27 mmol) in MeOH (5 mL), THF (1 mL), H2O (1 mL), and 2.5 N NaOH (2.5 mL) was heated to 50° C. for 1 h. The reaction was cooled, diluted with H2O, acidified to pH=5.5, and extracted with EtOAc. The extracts were washed with H2O, dried, and concentrated to yield the titled compound (93 mg, 70%). MS (ESI) 575 (M+H+).

Provenance & Evidence