HCID 13084736, compound → HCID 13084715, compound

Participants

Reaction Steps

2.88 Grams of 6-(4-morpholinobutyl)-3,4-dihydro-carbostyril and 10 ml of aniline were enclosed in a sealed tube and heated at 170°-200° C. for 5 hours. The reaction mixture was concentrated under a reduced pressure by removing aniline and the residue thus obtained was separated and purified by a silica-gel chromatography. Recrystallized from isopropanol-diisopropyl ether to obtain 0.36 g of 6-[4-(4-phenyl-1-piperazinyl)butyl-]3,4-dihydrocarbostyril in colorless prism-like crystals having the melting point of 151°-152° C.

Provenance & Evidence