Dimethyl Sulfate → HCID 21279524, compound

Participants

Reaction Steps

To a solution of the product of Example 1 (3 g) in dimethylformamide (20 ml) was added potassium t-butoxide (1.1 g) with cooling and stirring. Dimethyl sulphate (0.92 ml) was added dropwise, and the reaction mixture was stirred overnight. Addition to ice/water/ether and filtration, followed by recrystallisation from ethyl acetate gave 1.9 g of the desired product, mp 178°-180° C.

Provenance & Evidence