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HRID2291222

反应详情

EQUATION

反应方程式

HRID 2291222 的结构方程式

REACTANTS

反应物

2
结构：COC(=O)c1ccccc1S(=O)(=O)N=C=O
HCID156281

Benzoic acid, 2-(isocyanatosulfonyl)-, methyl ester

C9H7NO5S

结构：Cn1cc(Cl)nc(N)c1=O
HCID13062975

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)c1ccccc1S(=O)(=O)NC(=O)Nc1nc(Cl)cn(C)c1=O
HCID189318

Benzoic acid, 2-(((((6-chloro-3,4-dihydro-4-methyl-3-oxopyrazinyl)amino)carbonyl)amino)sulfonyl)-, methyl ester

C14H13ClN4O6S

收率 94.9%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

A mixture of 2.41 g of 2-methoxycarbonylphenylsulfonyl isocyanate, 1.6 g of 3-amino-5-chloro-1-methylpyrazin-2-one and 40 ml of absolute dioxane is refluxed for 3 hours. The reaction mixture is evaporated to dryness and the residue is crystallized by treatment with acetone. 3.8 g of 3-[3-(2-methoxycarbonylphenylsulfonyl)-ureido]-5-chloro-1-methylpyrazin-2-one with a melting point of 213°-214° C. are thus obtained.

WORKUP

后处理

  1. temperatureis refluxed for 3 hours
  2. customThe reaction mixture is evaporated to dryness
  3. customthe residue is crystallized by treatment with acetone