Diethyl Sulfate → HCID 19856557, compound

HRID 2291230Notes

Reaction equation

HRID 2291230 reaction equation
[Br:1][C:2]1[C:3](=[O:9])[NH:4][CH:5]=[C:6]([Br:8])[N:7]=1.[OH-].[Na+].C(=O)([O-])[O-].[Na+].[Na+].S(OCC)(O[CH2:22][CH3:23])(=O)=O>O>[CH2:22]([N:4]1[CH:5]=[C:6]([Br:8])[N:7]=[C:2]([Br:1])[C:3]1=[O:9])[CH3:23]

Participants

6

Reactant 4

HCID 6163Diethyl SulfateHCID 10340Sodium CarbonateHCID 14798Sodium HydroxideHCID 167408633,5-Dibromopyrazin-2(1H)-one

Product 1

HCID 19856557HCID 19856557, compoundYield 66.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

6.2 g of 3,5-dibromo-pyrazin-2-one are suspended in a mixture of 38 ml of water, 11.1 ml of 2N sodium hydroxide solution and 0.5 g of sodium carbonate. 4.3 g of diethyl sulfate are then added dropwise at 20°-25° C. and the mixture is subsequently stirred at the same temperature for 15 hours. The product is filtered off at 0° C., washed with ice-water and dried to give 4.6 g of 1-ethyl-3,5-dibromo-pyrazin-2-one.

Workup

  1. filtrationThe product is filtered off at 0° C.
  2. washwashed with ice-water
  3. customdried

Sources & evidence

ORD record
ord-75e0b2a06ca04636a4864bcee1bc2a46
Source dataset
uspto-grants-1989_01
Patent number
US04795486

Reaction notes

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