Lithium Hydroxide → HCID 86603444, compound

Participants

Reaction Steps

To a solution of (3-chloro-4-{3-[(2-chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-acetic acid methyl ester (42.8 mg, 0.068 mmol) and THF (2.5 mL) and H2O (0.8 mL), LiOH (3.4 mg, 0.14 mmol) was added and the reaction mixture was stirred for 12 h. The mixture was concentrated and H2O was added. The mixture was acidified with 1N HCl, extracted several times with EtOAc, and concentrated. The resulting oil was diluted in Et2O and acidified with 1.0 M HCl/Et2O. The mixture was then concentrated to give the product as a white solid (38.9 mg, 88%). MS(ES) m/e 616.2 [M+H]+.

Provenance & Evidence