反应详情

Crude 4,4,4-trinitrobutaldehyde (878 g, 4.24 mol) was dissolved in methanol (1000 mL) and cooled in an ice bath while NaBH4 (130.7 g 3.44 mol) was added portion-wise. The mixture was stirred at room temperature overnight under a nitrogen purge which removed much of the solvent. The thick suspension was hydrolyzed with 6N HCl (approx. 4 L) and the product extracted with CH2Cl2 (3×100 mL). The extracts were washed with water (1000 mL), saturated NaHCO3 (2×1000 mL), and water (1000 mL). The product solution was dried (MgSO4) and concentrated to yield 554 g (63%) of a yellow oil, n=1.4735 (19° C.). The infrared spectrum showed peaks at 3619, 3370, 2950, 2890, 1595, 1305, 1058 and 801 cm-1.

1. additionwas added portion-wise
2. custompurge which
3. customremoved much of the solvent
4. extractionthe product extracted with CH2Cl2 (3×100 mL)
5. washThe extracts were washed with water (1000 mL), saturated NaHCO3 (2×1000 mL), and water (1000 mL)
6. dry with materialThe product solution was dried (MgSO4)
7. concentrationconcentrated