HuagongsheHuagongshe Chemistry Print Report · For research reference only
rel-(2R,6S)-2,6-dimethylpiperazine → Sparfloxacin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | rel-(2R,6S)-2,6-dimethylpiperazine | HCID 6950261 | — |
| Reactant | 5-Amino-1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 13910947 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Sparfloxacin | HCID 60464 | — |
Reaction Steps
In the same manner as described in Example 1 (1), a mixture of 5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, cis-2,6-dimethylpiperazine, and dimethylformamide was stirred at room temperature for 24 hours to give 5-amino-1-cyclopropyl-6,8-difluoro-7-(cis-3,5-dimethyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, m.p. 258°-260° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04795751 |
| Source dataset | uspto-grants-1989_01 |
| ORD ID | ord-1e5b3746ca5e42739940983132139e2b |
| Source note | uspto-grants-1989_01 |