1-Piperazinecarboxaldehyde → HCID 14370090, compound

HRID 2291289Notes

Reaction equation

[C:1]([NH:4][C:5]1[C:14]([F:15])=[C:13](F)[C:12]([F:17])=[C:11]2[C:6]=1[C:7](=[O:24])[C:8]([C:21]([OH:23])=[O:22])=[CH:9][N:10]2[CH:18]1[CH2:20][CH2:19]1)(=[O:3])[CH3:2].[CH:25]([N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1)=[O:26]>>[C:1]([NH:4][C:5]1[C:14]([F:15])=[C:13]([N:30]2[CH2:31][CH2:32][N:27]([CH:25]=[O:26])[CH2:28][CH2:29]2)[C:12]([F:17])=[C:11]2[C:6]=1[C:7](=[O:24])[C:8]([C:21]([OH:23])=[O:22])=[CH:9][N:10]2[CH:18]1[CH2:20][CH2:19]1)(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 821911-Piperazinecarboxaldehyde

HCID 14006860HCID 14006860, compound

Product 1

HCID 14370090HCID 14370090, compound

Procedure

In the same manner as described in Example 1 (1), 5-acetylamino-1-cycloproply-6,7,8-trifluoro-1,4-dihydro-4- oxoquinoline-3-carboxylic acid (m.p. 247°-248° C.) was allowed to react with 1-formylpiperazine to give 5-acetylamino-1-cyclopropyl-6,8-difluoro-7-(4-formyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid.

Sources & evidence

ORD record: ord-236cb289faca463a83480da146f4b795
Source dataset: uspto-grants-1989_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04795751

Reaction notes

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