HCID 21279752, compound → HCID 21279772, compound

HRID 2291315Notes

Reaction equation

HRID 2291315 reaction equation
[F:1][C:2]([F:21])([F:20])[CH2:3][NH:4][C:5](=S)[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([S:13][CH2:14][CH2:15][CH2:16][C:17]#[N:18])[N:8]=1.[NH3:22].C(O)C>>[F:1][C:2]([F:21])([F:20])[CH2:3][N:4]=[C:5]([NH2:22])[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([S:13][CH2:14][CH2:15][CH2:16][C:17]#[N:18])[N:8]=1

Participants

3

Reactant 2

HCID 21279752HCID 21279752, compoundHCID 22020343Ethanol, reaction products with ammonia, distn. residues

Product 1

HCID 21279772HCID 21279772, compound

Procedure

A mixture of 4-[4-(3-[2,2,2-trifluoroethyl]thioureido)pyrimid-2-ylthio]butyronitrile (0.32 g.), saturated ethanol ammonia (20 ml.) and yellow mercuric oxide (0.5 g.) was stirred at room temperature for 20 hours and then filtered and the filtrate evaporated to dryness. The residue was recrystallised from a mixture of acetone and petroleum ether (b.p. 60°-80°) to give 4-[4-(2-[2,2,2-trifluoroethyl]guanidino)pyrimid-2-ylthio]butyronitrile (0.29 g.), m.p. 137°.

Workup

  1. filtrationfiltered
  2. customthe filtrate evaporated to dryness
  3. customThe residue was recrystallised from a mixture of acetone and petroleum ether (b.p. 60°-80°)

Sources & evidence

ORD record
ord-8e06db68156549aba4c31fea6f16bc84
Source dataset
uspto-grants-1989_01
Patent number
US04795755

Reaction notes

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