反应详情

A mixture of 4-[2-(3-[2,2,2-trifluoroethyl]thioureido)pyrid-6-ylthio]butyronitrile (29 g.), yellow mercuric oxide (29 g.) and a saturated solution of ammonia in EtOH (100 ml.) was stirred at room temperature for 24 hours and then filtered. The filtrate was evaporated to dryness and the residue triturated with petroleum ether (b.p. 60°-80°) and collected to give 4-[2-(2-[2,2,2-trifluoroethyl]guanidino)pyrid-6-ylthio]butyronitrile (24 g.), m.p. 89°-91°.

1. filtrationfiltered
2. customThe filtrate was evaporated to dryness
3. customthe residue triturated with petroleum ether (b.p. 60°-80°)
4. customcollected