HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 5-(4-[2-(2,2,2-Trifluoroethyl)guanidino]pyrimid-2-yloxy)valeramidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Methyl 5-(4-[2-(2,2,2-trifluoroethyl)guanidino]pyrimid-2-yloxy)valerimidate | HCID 21279807 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-(4-[2-(2,2,2-Trifluoroethyl)guanidino]pyrimid-2-yloxy)valeramidine hydrochloride | HCID 21279730 | 95.5% |
Reaction Steps
Methyl 5-(4-[2-(2,2,2-trifluoroethyl)guanidino]pyrimid-2-yloxy)valerimidate (1.5 g.) in MeOH (15 ml.) was treated with ammonium chloride (0.25 g.) and the solution stirred at room temperature for 2 hours. Ether was added until the solution became cloudy. Continued stirring caused precipitation of a solid which was filtered to give 5-(4-[2-(2,2,2-trifluoroethyl)guanidino]pyrimid-2-yloxy)valeramidine hydrochloride, (1.52 g.), m.p. 156°-158°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04795755 |
| Source dataset | uspto-grants-1989_01 |
| ORD ID | ord-d516a44a5aca40deb1aba7d8773b3ef1 |
| Source note | uspto-grants-1989_01 |