3-Chloro-1-propanol → HCID 178434690, compound

HRID 2291328Notes

Reaction equation

HRID 2291328 reaction equation
[OH-].[Na+].Cl[CH2:4][CH2:5][CH2:6][OH:7].[CH3:8][C:9]1[N:13]=[C:12]([SH:14])[NH:11][N:10]=1>O>[CH3:8][C:9]1[N:13]=[C:12]([S:14][CH2:4][CH2:5][CH2:6][OH:7])[NH:11][N:10]=1

Participants

5

Reactant 3

HCID 123133-Chloro-1-propanolHCID 14798Sodium HydroxideHCID 178434692HCID 178434692, compound

Product 1

HCID 178434690HCID 178434690, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of sodium hydroxide (0.4 g.) in water (5 ml.) was added 3-chloropropan-1-ol (0.83 ml.) and 3-methyl-5-mercapto-1,2,4-triazole (1.1 g.) and the mixture was heated at 100° for 1.5 hours. The solvent was evaporated and the residue was extracted twice with EtOAc/EtOH 50:50 v/v (20 ml.). The extracts were combined and evaporated to dryness. The residual solid was recrystallised from EtOAc to give 3-methyl-5-(3-hydroxypropylthio)-1,2,4-triazole (0.4 g.) which was used without further purification.

Workup

  1. temperaturethe mixture was heated at 100° for 1.5 hours
  2. customThe solvent was evaporated
  3. extractionthe residue was extracted twice with EtOAc/EtOH 50:50 v/v (20 ml.)
  4. customevaporated to dryness
  5. customThe residual solid was recrystallised from EtOAc

Sources & evidence

ORD record
ord-4fa983185d9c4d6fa7363f7c801ca72d
Source dataset
uspto-grants-1989_01
Patent number
US04795755

Reaction notes

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