HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1,1-Trifluoro-2-isothiocyanatoethane → 1-(2-Hydroxyethyl)-3-[3-(2,2,2-trifluoroethyl)thioureido]pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1,1-Trifluoro-2-isothiocyanatoethane | HCID 13883777 | — |
| Reactant | 2-(3-Amino-1H-pyrazol-1-yl)ethan-1-ol | HCID 21279853 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-(2-Hydroxyethyl)-3-[3-(2,2,2-trifluoroethyl)thioureido]pyrazole | HCID 54373978 | 46.1% |
Reaction Steps
A mixture of 2,2,2-trifluoroethylisothiocyanate (13.8 g.) and 3-amino-1-(2-hydroxyethyl)pyrazole (12.5 g.) in acetonitrile dried over 4A molecular sieve (30 ml.) was stirred at room temperature for 4 hours. A precipitate formed after 30 minutes. Filtration gave 1-(2-hydroxyethyl)-3-[3-(2,2,2-trifluoroethyl)thioureido]pyrazole (12.1 g.; 46%), m.p. 145°-146°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04795755 |
| Source dataset | uspto-grants-1989_01 |
| ORD ID | ord-13ce0ae1ea97457cb53735bdae982281 |
| Source note | uspto-grants-1989_01 |