Ammonium Chloride → HCID 21279721, compound

HRID 2291337Notes

Reaction equation

HRID 2291337 reaction equation
[F:1][C:2]([F:22])([F:21])[CH2:3][N:4]=[C:5]([NH2:20])[NH:6][C:7]1[N:11]=[CH:10][N:9]([CH2:12][CH2:13][CH2:14][CH2:15][C:16](=[NH:19])OC)[N:8]=1.[Cl-:23].[NH4+:24]>CO>[ClH:23].[F:1][C:2]([F:22])([F:21])[CH2:3][N:4]=[C:5]([NH2:20])[NH:6][C:7]1[N:11]=[CH:10][N:9]([CH2:12][CH2:13][CH2:14][CH2:15][C:16]([NH2:24])=[NH:19])[N:8]=1

Participants

4

Reactant 2

HCID 25517Ammonium ChlorideHCID 21279830HCID 21279830, compound

Product 1

HCID 21279721HCID 21279721, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of methyl 5-[3-(2-[2,2,2-trifluoroethyl]guanidino)-1,2,4-triazol-1-yl]valerimidate (1 g.) in MeOH (12 ml.) and ammonium chloride (0.162 g.) was stirred for 3 hours at room temperature. The solvent was removed to give 5-[3-(2-[2,2,2-trifluoroethyl]guanidino)-1,2,4-triazol-1-yl]valeramidine hydrochloride as a yellow gum, which was used without further purification.

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-72bb78e56d744dde827d3ebd05b43562
Source dataset
uspto-grants-1989_01
Patent number
US04795755

Reaction notes

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