HCID 178475142, compound → HCID 178434608, compound

HRID 2291339Notes

Reaction equation

HRID 2291339 reaction equation
[C:1]([NH:4][NH:5][C:6](=[NH:25])[CH2:7][CH2:8][CH2:9][CH2:10][N:11]1[CH:15]=[N:14][C:13]([NH:16][C:17]([NH2:24])=[N:18][CH2:19][C:20]([F:23])([F:22])[F:21])=[N:12]1)(=O)[CH3:2]>CC(C)=O>[CH3:2][C:1]1[N:25]=[C:6]([CH2:7][CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[N:14][C:13]([NH:16][C:17]([NH2:24])=[N:18][CH2:19][C:20]([F:23])([F:22])[F:21])=[N:12]2)[NH:5][N:4]=1

Participants

3

Reactant 1

HCID 178475142HCID 178475142, compound

Product 1

HCID 178434608HCID 178434608, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

N-Acetylamino-5-[3-(2-[2,2,2-trifluoroethyl]guanidino)-1,2,4-triazol-1-yl]valeramidine (0.55 g.) was heated at 170° for 12 minutes. The resulting glass was boiled with acetone and the solid obtained crystallised from acetonitrile to give 3-methyl-5-(4-[3-(2-[2,2,2-trifluoroethyl]guanidino)-1,2,4-triazol-1-yl]butyl)-1,2,4-triazole as a white solid (0.34 g., 65%), m.p. 175°-176°.

Workup

  1. customthe solid obtained
  2. customcrystallised from acetonitrile

Sources & evidence

ORD record
ord-9b4d3c15274849f3bffc7128e1a5589b
Source dataset
uspto-grants-1989_01
Patent number
US04795755

Reaction notes

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