反应详情

maleate, m.p. 182°-184° (yield 25%). The 4-[4-(2-[2,2,3,3-tetrafluoropropyl]guanidino)pyrimid-2-yloxy]butyramidine used as starting material may be prepared as follows. The second, third and fourth parts of Example 34 in European Patent Publication No.30092 were repeated, using 2,2,3,3-tetrafluoropropylisothiocyanate in place of 2,2,2-trifluoroethylisothiocyanate, to give 4-[2-(2,2,3,3-tetrafluoropropyl)guanidino]-2methylsulphinylpyrimidine. Using this intermediate, and 3-cyanopropanol in place of 4-cyanobutanol, the second, third and fourth parts of Example 24 were repeated to give the required starting material.

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