反应详情

Sodium metaperiodate (1.3 g.) in water (5 ml.) was added to a solution of 4-amino-2-methylthiopyrimidine (0.7 g.) in water (10 ml.) at 90°, and the solution kept at 90° for 1 hour. A further 1.3 g. of sodium metaperiodate was added and the solution heated a further 0.5 hours and then cooled to room temperature. The mixture was filtered and the filtrate evaporated to dryness. The residue was triturated with MeOH and the suspension filtered and then the filtrate was evaporated to dryness. The residue was triturated with acetonitrile and the insoluble solid collected to give 4-amino-2-methylsulphinylpyrimidine (0.7 g.) which was used without further purification.

1. temperaturethe solution heated a further 0.5 hours
2. filtrationThe mixture was filtered
3. customthe filtrate evaporated to dryness
4. customThe residue was triturated with MeOH
5. filtrationthe suspension filtered
6. customthe filtrate was evaporated to dryness
7. customThe residue was triturated with acetonitrile
8. customthe insoluble solid collected