p-Toluenesulfonic acid → 2H-Pyran, tetrahydro-2-(4-iodophenoxy)-

Participants

Reaction Steps

10 Grams of p-iodophenol, 8 ml of dihydropyrane and a catalytic amount of p-toluenesulfonic acid was dissolved in 30 ml of anhydrous diethyl ether, and the mixture was stirred at room temperature for 2 hours. The reaction mixture was washed with water, dried then the solvent was removed by evaporation to yield 12.4 g of 4-(2-tetrahydropyranyloxy)-1-iodobenzene in the form of yellow oily substance. Boiling point: 84°-87° C. (at 25 mm Hg).

Provenance & Evidence