Sodium Sulfate → HCID 19883160, compound

Participants

Reaction Steps

To an anhydrous tetrahydrofuran solution containing 2.4 g of 4-[4-(2-tetrahydropyranyloxy)phenyl]-3-butynyl acetate was added 1 g of lithium aluminium hydride and the mixture was refluxed for 12 hours. After the reaction was completed, an aqueous solution saturated with sodium sulfate was slowly added to the reaction mixture, and the precipitation formed were removed by filtration, then the filtrate was dried with anhydrous sodium sulfate, and concentrated to dryness. The residue thus obtained was purified by means of a silica gel column chromatography to yield 2 g of 4-[(2-tetrahydropyranyloxy)phenyl]-3(E)-butenyl alcohol as in the form of colorless oily substance.

Provenance & Evidence