Methyl Salicylate → Benzamide, 2-hydroxy-N-octyl-

HRID 2291376Notes

Reaction equation

CO[C:3](=[O:11])[C:4]1[C:5](=[CH:7][CH:8]=[CH:9][CH:10]=1)[OH:6].[CH2:12]([NH2:20])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]>>[CH2:12]([NH:20][C:3](=[O:11])[C:4]1[C:5](=[CH:7][CH:8]=[CH:9][CH:10]=1)[OH:6])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]

Participants

Reactant 2

HCID 4133Methyl Salicylate

HCID 8143Octylamine

Product 1

HCID 10220570Benzamide, 2-hydroxy-N-octyl-

Procedure

N-octyl salicylic acid amide was prepared, using the process described in Example 1, from salicylic acid methyl ester and n-octylamine (quantities used 1 mole:1 mole) and purified and recrystallized in the same way as described in Example 1.

Workup

custompurified
customrecrystallized in the same way

Sources & evidence

ORD record: ord-0b5b4f977dd84162b7fe8581afb644f0
Source dataset: uspto-grants-1989_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04795832

Reaction notes

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