HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2291489Generated: October 31, 2026
Aniline → 3-Ethyl 5-methyl 6-(chlorodifluoromethyl)-4-(phenylamino)-2-(trifluoromethyl)-3,5-pyridinedicarboxylate
https://huagongshe.com/reaction/2291489
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Ethyl 5-methyl 4-chloro-6-(chlorodifluoromethyl)-2-(trifluoromethyl)-3,5-pyridinedicarboxylate | HCID 14013759 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-Ethyl 5-methyl 6-(chlorodifluoromethyl)-4-(phenylamino)-2-(trifluoromethyl)-3,5-pyridinedicarboxylate | HCID 14013826 | — |
Reaction Steps
This compound was prepared as described in Example 37: 5.0 g (0.013 mol) of product of Example 28, 3.6 ml (0.039 mol) of aniline, 1.3 g (0.013 mol) of triethylamine in 30 ml of DMF were reacted at room temperature for 16 hours and heated to 35° C. for 20 minutes The residue was recrystallized in hot hexane affording 4.0 g (68.0%) of product as a beige solid; mp 91°-92° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04797149 |
|---|
| Source dataset | uspto-grants-1989_01 |
|---|
| ORD ID | ord-3545d651f25c48bd8cbc8e6e018f40b0 |
|---|
| Source note | uspto-grants-1989_01 |
|---|
