Hydrochloric Acid → HCID 86742659, compound

Participants

Reaction Steps

13 mg (0.026 mmol) of IV is dissolved in 1 ml of acetonitrile containing 0.15 ml of conc. HCl. The reaction mixture is stirred at room temperature for 2.5 hours. TLC on silica gel with EtOAc--MeOH--NH4OH (80:20:1) as the mobile phase shows that the trimethylsilylethyloxycarbonyl protective group has been completely removed after 2.5 hours. The reaction solution is evaporated, whereupon an NMR analysis is run in D2O+ deuterated acetonitrile. ##STR4## 1-CH2 -imidazole 4.18 t, --CH2NHCO 3.52 t, H3N+CH2 -- 3.18 t, 4-CH2 -imidazole about 3.0 t, --CH2S-- 3.0 t, --COCH2 -- 2.57 t.

Provenance & Evidence