2-Methoxyethanol → HCID 14350667, compound

Participants

Reaction Steps

A mixture of 9-bromo-5,6-dichloro-7-methoxy-9a-propyl-1,2,9,9a-tetrahydro-3H-fluoren-3-one (6.29 g, 0.0157 mole) and silver nitrate (7.89 g, 0.047 mol) in 2-methoxyethanol (200 ml) and H2O (100 ml) was heated at reflux for 2 hours, filtered and evaporated to dryness. Chromatography of the residue on silica gel eluted with ethyl acetate-hexane (1:1) gave 1.2 g of 5,6-dichloro-9-hydroxy-7-methoxy-9a-propyl-1,2,9,9a-tetrahydro-3H-fluoren-3-one which melted at 173°-5° C. and was used in Step C without further purification.

Provenance & Evidence