Hydrochloric Acid → HCID 14350673, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl [(9-acetoxy-5,6-dichloro-3-oxo-9a(R)-propyl-2,3,9,9a-tetrahydro-1H-fluoren-7-yl)oxy]acetate (4.27 g, 0.0094 mol), methanol (75 ml) and 1N sodium hydroxide (21 ml) was stirred at 25° C. for 4 hours, diluted with water (250 ml), acidified with HCl and extracted with ether and methylene chloride. The combined organic extracts were combined, washed with H2O, dried over MgSO4 and evaporated in vacuo to give [(5,6-dichloro-9-hydroxy-3-oxo-9a(R)-propyl-2,3,9,9a-tetrahydro-1H-fluoren-7-yl)oxy]acetic acid which melted at 206°-208° C.

Provenance & Evidence