HCID 86742660, compound → HCID 22841132, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl [(9-amino-5,6-dichloro-3-oxo-9a(R)-propyl-2,3,9,9a-tetrahydro-1H-fluoren-7-yl)oxy]acetate hydrochloride (497.5 mg, 0.002 mole) is dissolved in a mixture of ethanol (17 ml), water (3 ml) and 1N sodium hydroxide (5 ml). The mixture is stirred at 25° C. for 10 hours, evaporated to dryness in vacuo and the residue dissolved in water (20 ml) and carefully neutralized with hydrochloric acid to the isoelectric points whereby a precipitate separates. The product is removed by filtration, washed with water and dried to give [(9-amino-5,6-dichloro-3-oxo-9a(R)-propyl-2,3,9,9a-tetrahydro-1H-fluoren-7-yl)oxy]acetic acid.

Provenance & Evidence