Sodium Hydroxide → Hydrochloric Acid

Participants

Reaction Steps

Ethyl [(3-oxo-9a(R)-propyl-2,3,9,9a-tetrahydro-5,6,9-trichloro-1H-fluoren-7-yl)oxy]acetate (4.31 g, 0.01 mole) was stirred with ethanol (50 ml) and 1N sodium hydroxide (15 ml) for 12 hours at 25° C. The solution was evaporated in vacuo and the residue dissolved in water. Acidification with hydrochloric acid gave [(3-oxo-9a(R)-propyl-2,3,9,9a-tetrahydro-5,6,9-trichloro-1H-fluoren-7-yl)oxy]acetic acid which was purified by column chromatography on silica gel (400 g) eluting with methylene chloride/tetrahydrofuran/acetic acid, 50/2/1 (v/v/v).

Provenance & Evidence