反应详情

The 1-[(4-methoxyphenoxy)carbonylmethyl]-4-(3,4,5-trimethoxybenzyl)piperazine dihydrochloride (8.0 g) obtained above is added to a 5% aqueous potassium carbonate solution (100 ml), and the produced oily substance is extracted with chloroform (150 ml). The chloroform layer is dried over anhydrous magnesium sulfate, and the solvent is distilled off under reduced pressure. The residue is recrystallized from a mixture of ethyl acetate and n-hexane to give 1-[(4-methoxyphenoxy)carbonylmethyl]-4-(3,4,5-trimethoxybenzyl)piperazine (5.2 g).

1. extractionthe produced oily substance is extracted with chloroform (150 ml)
2. dry with materialThe chloroform layer is dried over anhydrous magnesium sulfate
3. distillationthe solvent is distilled off under reduced pressure
4. customThe residue is recrystallized from a mixture of ethyl acetate and n-hexane