Methanesulfonyl chloride → HCID 21278918, compound

Participants

Reaction Steps

1-(3-Fluoro-4-aminophenyl)-4-(4-aminophenethyl)piperazine (0.06 g) was dissolved in pyridine (4.5 ml) and methanesulphonyl chloride (0.13 g) was added. The mixture was stirred at room temperature overnight, the pyridine removed by evaporation, and the residue chromatographed over silica, developing and eluting with 10% methanol in dichloromethane. The fractions containing the product were evaporated to give a residue (0.30 g) which was crystallized from methanol, yielding the pure title compound, (0.016 g), m.p. 232°-4°.

Provenance & Evidence