1-Acetyl-4-(4-nitrophenyl)piperazine → 1-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-one

Participants

Reaction Steps

1-Acetyl-4-(4-nitrophenyl)piperazine [Ger. Pat. No. 1,239,940; Chem. Abs., 67, 101031z (1967)] (76.64 g) in ethanol (1000 ml) was hydrogenated over Raney nickel at 40° and 60 p.s.i. for 4 hours. The catalyst was then filtered off and the filtrate evaporated to give a residual solid which was crystallised from ethyl acetate, yield of the title compound 47.88 g, m.p. 129°-130°.

Provenance & Evidence