反应详情

To 1-Acetyl-4-(4-aminophenyl)piperazine (10.96 g) in ice-cold pyridine (100 ml) was added methanesulphonyl chloride (6.3 g) dropwise. The mixture was then stirred at ambient temperature overnight and the pyridine removed in vacuo. The residue was triturated with aqueous sodium bicarbonate, and the resulting solid was washed (water) and crystallized from methanol/ethyl acetate (charcoal). The yield of the title compound was 9.97 g, m.p. 165°-7°.

1. customthe pyridine removed in vacuo
2. customThe residue was triturated with aqueous sodium bicarbonate
3. washthe resulting solid was washed (water)
4. customcrystallized from methanol/ethyl acetate (charcoal)