Isoamyl Nitrite → HCID 21278874, compound

HRID 2291581Notes

Reaction equation

HRID 2291581 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[N:10]([CH2:11][C:12]([N:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)=[O:13])[C:9](=[O:20])[S:8][C:5]2=[N:6][CH:7]=1.[N:21](OCCC(C)C)=[O:22]>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]2[N:10]([CH2:11][C:12]([N:14]3[CH2:15][CH2:16][N:17]([N:21]=[O:22])[CH2:18][CH2:19]3)=[O:13])[C:9](=[O:20])[S:8][C:5]2=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 8053Isoamyl NitriteHCID 19837972HCID 19837972, compound

Product 1

HCID 21278874HCID 21278874, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of 6-chloro-2-oxo-1-[(1-piperazinyl)carbonylmethyl]-1,2-dihydrothiazolo[5,4-b]pyridine (1.40 g) in chloroform (15 ml) was added isoamyl nitrite (3.0 ml) and the mixture was stirred for 11 hours at room temperature. Precipitated crystals were collected by filtration, washed with chloroform and dried to give colorless crystals of 6-chloro-2-oxo-1-[(4-nitroso-1-piperazinyl)carbonylmethyl]-1,2-dihydrothiazolo[5,4-b]pyridine (1.33 g).

Workup

  1. customPrecipitated crystals
  2. filtrationwere collected by filtration
  3. washwashed with chloroform
  4. customdried

Sources & evidence

ORD record
ord-f6ffd4bff3f14eccb43ed6bc2543578d
Source dataset
uspto-grants-1989_01
Patent number
US04797399

Reaction notes

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