HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 21278866, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-[2-(4-Aminopiperazin-1-yl)-2-oxoethyl]-5-chloro-1,3-benzothiazol-2(3H)-one | HCID 21278851 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 21278866 | HCID 21278866 | 33.7% |
Reaction Steps
A mixture of 5-chloro-3-[(4-amino-1-piperazinyl)carbonylmethyl]-2-benzothiazolinone (0.85 g), anhydrous potassium carbonate (430 mg), dichloromethane (40 ml), dioxane (10 ml) and ethyl chloroformate (339 mg) was stirred for 1.5 hours at room temperature. The insoluble materials were filtered off and the filtrate was concentrated under reduced pressure. The residue was recrystallized from a mixture of chloroform and dioxane to give colorless crystals of 5-chloro-3-[(4-ethoxycarbonylamino-1-piperazinyl)carbonylmethyl]-2-benzothiazolinone (0.35 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04797399 |
| Source dataset | uspto-grants-1989_01 |
| ORD ID | ord-64b4d959debc4b35ab29c9831f5cb0cd |
| Source note | uspto-grants-1989_01 |