Formaldehyde → HCID 21278882, compound

Participants

Reaction Steps

A solution of 5-chloro-3-[(4-amino-1-piperazinyl)carbonylmethyl]-2-benzothiazolinone (5.0 g) and 37% formaldehyde solution (1.38 ml) in acetonitrile (150 ml) was stirred for 1.5 hours at room temperature. The reaction mixture was concentrated under reduced pressure. The residue was subjected to column chromatography on silica gel (50 g) eluting with a mixture of chloroform and methanol (50:1). The fractions containing the desired compound were combined and concentrated under reduced pressure. The residue was recrystallized from ethanol (200 ml) to give colorless crystals of 5-chloro-3-[(4-methyleneamino-1-piperazinyl)carbonylmethyl]-2-benzothiazolinone (5.1 g).

Provenance & Evidence