Acetic Acid → HCID 178465650, compound

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A mixture of 5-chloro-3-{[4-[N-(p-nitrobenzyloxycarbonyl)acetimidoylamino]-1-piperazinyl]carbonylmethyl}-2-benzothiazolinone (2.0 g), acetic acid (0.3 ml), water (3 ml), 10% palladium on carbon (2.0 g) in tetrahydrofuran (40 ml) and methanol (20 ml) was incubated under an atmosphere of hydrogen for 3 hours. Palladium on carbon was filtered off, and the filtrate was coevaporated with ethanol. The residue obtained was purified by aluminum column chromatography, treated with hydrogen chloride in ethanol, and recrystallized from a mixture of water, ethanol and ether to give yellow crystals of 5-chloro-3-[(4-acetimidoylamino-1-piperazinyl)carbonylmethyl]-2-benzothiazolinone hydrochloride (0.3 g).

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