Hydrochloric Acid → HCID 21278850, compound

Participants

Reaction Steps

To a solution of hydroxylamine hydrochloride (25.2 g) in a mixed solvent of acetonitrile (300 ml) and 6N-hydrochloric acid (150 ml), was added 5-chloro-3-[(4-benzylideneamino-1-piperazinyl)carbonylmethyl]-2-benzothiazolinone (15 g). The resulting solution was stirred overnight at room temperature. After stirring for five hours under ice cooling, the crystalline precipitates were filtered, and washed successively with water (30 ml) and methylene chloride (75 ml). This product was suspended in water (30 ml) and then filtered to give 5-chloro-3-[(4-amino-1-piperazinyl)carbonylmethyl]-2-benzothiazolinone hydrochloride (8.60 g).

Provenance & Evidence