Water → HCID 178479589, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-chloro-1-[(4-benzylideneamino-1-piperazinyl)carbonylmethyl]-2,3-indolinedione (1.5 g) and hydroxylamine hydrochloride (2.5 g) in acetonitrile (100 ml), conc. hydrochloric acid (50 ml), and water (50 ml) was heated at 40° C. for 2 hour. The reaction mixture was concentrated up to 20 ml and the precipitates appeared were filtered, and air-dried. This crude material was recrystallized from aqueous methanol at first, and for water finally to give 6-chloro-1-[(4-amino-1-piperazinyl)carbonylmethyl]-3-hydroxyimino-2-indolinone hydrochloride (0.54 g).

Provenance & Evidence