HCID 131715451, compound → HCID 131715811, compound

Participants

Reaction Conditions

Reaction Steps

In 30 ml of N,N-dimethylformamide is dissolved 4.76 g of sodium 7β-[2-(2-aminothiazol-4-yl)acetamido]-3-acetoacetoxymethyl-ceph-3-em-4-carboxylate and the solution is cooled to -5° C. With stirring, 5.0 g of 1-iodo-2-methylpropylcyclohexane carboxylate is added dropwise, followed by stirring for further 5 minutes. Thereafter, following the procedure of Example 1, 2.5 g of the title compound is obtained.

Provenance & Evidence