Methyl chloroacetate → HCID 13336496, compound

HRID 2291603Notes

Reaction equation

HRID 2291603 reaction equation
Cl[CH2:2]C(OC)=O.[CH2:7]([C:9]1([C:18]([C:20]2[CH:31]=[CH:30][C:23]([O:24][CH2:25][C:26]([O:28]C)=O)=[CH:22][CH:21]=2)=[O:19])[CH2:13][C:12]2[CH:14]=[CH:15][CH:16]=[CH:17]C=2O1)[CH3:8].[OH2:32].[NH3:33]>>[CH2:8]([C:7]1[O:32][C:17]2[CH:16]=[CH:15][CH:14]=[CH:12][C:13]=2[C:9]=1[C:18]([C:20]1[CH:21]=[CH:22][C:23]([O:24][CH2:25][C:26]([NH2:33])=[O:28])=[CH:30][CH:31]=1)=[O:19])[CH3:2]

Participants

4

Reactant 3

HCID 7295Methyl chloroacetateHCID 12896473Azane;hydrateHCID 67926483HCID 67926483, compound2×

Product 1

HCID 13336496HCID 13336496, compound

Procedure

According to the Procedure B of Example 1, the intermediate of the Example 3 was reacted with methyl chloroacetate. The resulting product methyl 4-(2-ethyl-benzofuroyl)phenoxyacetate (Compound 11) was treated with concentrated ammonia water (28%) 100 ml and was stirred under ice-cooled condition for three hours. The white powder this obtained, after drying was recrystallized from methanol.

Workup

  1. temperaturecooled condition for three hours
  2. customThe white powder this obtained, after drying
  3. customwas recrystallized from methanol

Sources & evidence

ORD record
ord-bd466c02b0694c68a2d3cac719b175fa
Source dataset
uspto-grants-1989_01
Patent number
US04797415

Reaction notes

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