Malonic Acid → HCID 70388328, compound

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Reaction Steps

A stirred solution of 17.6 g 4H-4-phenyl-thieno[3,2-c][1]benzopyran-2-carboxaldehyde, 12.5 g malonic acid and 24 ml pyridine is slightly heated until a clear solution is obtained. Subsequently, 1 ml piperidine is added and the solution slowly heated to reflux. After 3 h reflux, the solution is cooled and poured into water. After acidification with hydrochloric acid, the crude product is filtered off, dried, recrystallized from ethyl acetate and dried in vacuo. Pure 3-(4H-4-phenyl-thieno[3,2-c][1]benzopyran-2yl)propenoic acid is obtained; m.p. 235° C. (decomposition).

Provenance & Evidence